- Howard Gillman: Chancellor
- Enrique Lavernia: Provost & Executive Vice Chancellor
- Michael P. Clark: Interim Vice Provost and Executive Vice Chancellor (’14-’15)
- Ramona Agrela: Associate Chancellor, Human Resources
- Michael Arias: Associate Chancellor and Chief of Staff
- Wendell Brase: Vice Chancellor, Administrative & Business Services
- Ria Carlson: Associate Chancellor, Strategic Communications
- Howard Federoff: Vice Chancellor, Health Affairs; Chief Executive Officer, UC Irvine Health System
- Diane Geocaris: Chief Campus Counsel
- John Hemminger: Vice Chancellor, Research (’14-’15)
- James Hicks: Interim Vice Chancellor, Research
- Brian T. Hervey: Interim Vice Chancellor, University Advancement; Associate Vice Chancellor, Health Advancement
- Gregory Leet: Vice Chancellor, University Advancement ('14-'15)
- Jeff Lefkoff: Associate Executive Vice Chancellor and Chief of Staff, Academic Affairs
- Meredith Michaels: Vice Chancellor, Planning & Budget
- Kirsten Quanbeck: Associate Chancellor, Equity, Diversity & Inclusion
- Thomas Parham: Vice Chancellor, Student Affairs
